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E2F1 — MYBL2

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → B-Myb (MYBL2) (transcription, activates) Takahashi et al., Genes Dev 2000, Zhu et al., EMBO J 2004, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYBL2 — E2F1 (direct interaction, two hybrid) Giangrande et al., Mol Cell Biol 2003

Text-mined interactions from Literome

Hanada et al., Mol Carcinog 2006 : Also found in breast tumors with high levels is B-Myb , a transcription factor whose expression is activated by E2F1/3 at the late G1 phase and the level is sustained through the S phase ... As EGFR lacks DNA binding domain but contains transactivational activity and E2F1 activates B-Myb expression in the G1/S phase, we further reasoned that nuclear EGFR might cooperate with E2F1 leading to activation of B-Myb ... Consistently, forced expression of both EGFR and E2F1 in EGFR-null CHO cells greatly enhanced B-Myb promoter activity, compared to the vector control and expression of EGFR or E2F1 alone ... Promoter mutagenesis studies showed that EGF induced activation of B-Myb promoter required both E2F and EGFR target sites
Nakajima et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : Activation of B-Myb by E2F1 in hepatocellular carcinoma
Sahin et al., International journal of biological sciences 2010 : For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb , TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle ... For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb , TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle
Lam et al., Gene 1995 : We demonstrate here that activity of the human B-myb promoter is regulated during the cell cycle by the E2 transcription factor ( E2F )
Lyon et al., Crit Rev Oncog 1994 (Neoplasms) : Consistent with this conclusion, B-myb transcription is controlled by the transcription factor E2F , which has been implicated in cell cycle regulation of a number of genes involved in DNA synthesis
Lam et al., EMBO J 1993 : An E2F binding site mediates cell-cycle regulated repression of mouse B-myb transcription
Bennett et al., Oncogene 1996 : E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts