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EPHB2 — NPY6R

Text-mined interactions from Literome

Roberts et al., Br J Pharmacol 2001 : PP2 also prevented the phosphorylation of Erk by UK14304
Zhen et al., Mol Pharmacol 2001 : Moreover, PP2 ( 20 nM ), an inhibitor of Src, blocked D ( 4 ) receptor mediated SHC phosphorylation and ERK activation
Wei et al., Am J Physiol Cell Physiol 2001 : The tyrosine kinase inhibitors genistein and PP-2 blocked JNK, but not ERK1/2 and p38, activation
Galve-Roperh et al., Mol Pharmacol 2002 (Astrocytoma) : HU-210 induced ERK activation was inhibited by tyrphostin AG1478 and PP2 , widely employed inhibitors of the epidermal growth factor receptor ( EGF ( R ) ) and the Src family of cytosolic tyrosine kinases, respectively
Shah et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The Src inhibitor, PP2 , the C-terminal Src kinase (Csk), and dominant negative Pyk2 attenuated ERK1/2 activation by GnRH and PMA but not by EGF
Kumar et al., Blood 2003 : PI3K and ERK1/2 phosphorylation was significantly inhibited by PP2 , thereby suggesting that both of these pathways may be activated via Src kinase
Shah et al., J Biol Chem 2003 : GnRH induced activation of ERK1/2 was attenuated by the selective Src kinase inhibitor PP2 and the negative regulatory C-terminal Src kinase in GT1-7 cells but not in HEK293 cells
Gendron et al., J Biol Chem 2003 : Furthermore, we found that activation of protein phosphatase 2A (PP2A) by Coll I was required for both Coll I-mediated activation of Erk , and inhibition of Fas induced caspase-8 activation and apoptosis
Sanders et al., Am J Physiol Gastrointest Liver Physiol 2004 : Both dominant negative Src and Src inhibitor PP2 strongly inhibited collagen IV ERK activation in Caco-2 intestinal epithelial cells
Scapoli et al., Oncogene 2004 : ERK1/2 activation by asbestos was inhibited by either PP2 or AG1478
Xu et al., Hypertension 2004 : An Src kinase inhibitor, pp2 , and MEK inhibitor, PD98059, blocked the ERK1/2 phosphorylation and eNOS expression
Øvrevik et al., Toxicological sciences : an official journal of the Society of Toxicology 2004 : Moreover, PP2 inhibited silica induced phospho-ERK1/2 to near-control levels, whereas phospho-p38 was not significantly reduced by the SFK inhibitor
Ichiki et al., Biochem Biophys Res Commun 2004 : GM6001, a matrix metalloproteinase inhibitor, and PP2 , a Src family protein kinase inhibitor, suppressed 15-d-PGJ2- and TZDs induced phosphorylation of EGF-R and PDGFbeta-R as well as activation of ERK1/2 and Akt
Zhao et al., J Biol Chem 2005 (Cell Transformation, Neoplastic) : In addition, the Fyn inhibitor PP2 blocked 2-AG induced Fyn kinase activity and ERK phosphorylation and activity
Garcia et al., Blood 2005 (MAP Kinase Signaling System) : VWF induced Erk2 phosphorylation and thromboxane A2 ( TXA2 ) release were completely blocked by PP2 , an Src family kinase inhibitor, suggesting that Erk is downstream of Src family kinases
Lee et al., Arch Toxicol 2006 : H2O2 induced ERK activation was inhibited by the Src family selective inhibitor PP2 and the epidermal growth factor receptor inhibitor AG1478
Li et al., Biochem Biophys Res Commun 2006 : Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation ... Specific epidermal growth factor receptor (EGFR) inhibitor AG1478 and specific Src inhibitor PP2 inhibited IR-induced ERK1/2 activation but phosphatidylinositol-3 kinase inhibitor wortmannin did not
Yumoto et al., Mol Cell Biochem 2006 (Disease Progression) : Thus, PP2A regulates the ERK activity in a cell-specific manner, and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes
Watson et al., Mol Cell Neurosci 2007 : RGD induced effects were reduced by the NMDA receptor antagonist MK801, and ERK1/2 signaling was specifically inhibited by ifenprodil and PP2 , indicating a functional connection between integrins, Src and NR2B containing NMDA receptors
Chaturvedi et al., Am J Physiol Cell Physiol 2007 (Mechanotransduction, Cellular) : PP2 also blocked strain induced phosphorylation of FAK-Tyr ( 576 ) and ERK-Thr ( 202 ) /Tyr ( 204 ) but not FAK-Tyr ( 397 )
Hooper et al., Neurosci Lett 2007 : PP2 inhibited ERK phosphorylation ; therefore, Src mediates CgA induced ERK phosphorylation leading to iNOS expression and NO production
Smolinska et al., Mol Immunol 2008 : Interestingly, however, PP2 had no significant effect on the activation of NF-kappaB, or on p42/44 ERK , p46/54 JNK or p38 MAPK phosphorylation
Lee et al., J Pharmacol Sci 2007 : Ang II-enhanced cell migration was inhibited by SB203580 ( a p38 MAPK inhibitor ) and piceatannol ( a spleen tyrosine kinase inhibitor ), but only partially by PD98059 ( an ERK inhibitor ) and PP2 ( a Src inhibitor ) ... The phosphorylation of ERK1/2 stimulated by Ang II was suppressed by PD98059, piceatannol, and PP2
Yamaguchi et al., Brain Tumor Pathol 2005 (Astrocytoma) : However, SPR mediated ERK1/2 phosphorylation is significantly reduced by the Src kinase inhibitor PP2
Kim et al., Int J Neuropsychopharmacol 2008 : Accordingly, PP2A regulates acute dose- and time dependent changes in MEK-ERK-p90RSK phosphorylation after haloperidol treatment
Lin et al., Am J Physiol Cell Physiol 2008 : The Src inhibitor PP2 blocked pilocarpine induced ERK activation and EGF receptor phosphorylation, without affecting ERK activation by carbachol
Daoud et al., Placenta 2008 : PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation ... Furthermore, we showed that transient activation of ERK1/2 by FBS is independent of SFK and that PP2 induces rapid activation of p38
Chung et al., Br J Pharmacol 2009 : The ERK activation, NF-kB translocation and PDGF-BB production were blocked by PP2 , U73122 and PD98059
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK) , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Park et al., Am J Physiol Cell Physiol 2009 : Especially, phosphorylation of caveolin-1 is attenuated by AG1478, herbimycin A ( tyrosine kinase inhibitors ), and pyrazolopyrimidine 2 ( PP2, Src inhibitor ) and EGF induced ERK activation was blocked by PP2 , methyl-beta-cyclodextrin ( MbetaCD ), caveolin-1 small interfering RNA ( siRNA ), LY-294002 [ phosphoinositol-3 kinase inhibitor ( PI3K ) ], and Akt inhibitor ... EGF also significantly increases [ ( 3 ) H ] thymidine incorporation and cell number, which were significantly blocked by AG 1478, PP2 , MbetaCD, caveolin-1 siRNA, FAK siRNA, LY-294002, and PD-98059 ( ERK inhibitor )
Yang et al., Eur J Pharmacol 2010 : Both plumbagin stimulated ERK1/2 and Akt activities were attenuated by PP2 , a Src inhibitor
Kyotani et al., J Pharmacol Sci 2010 (Atherosclerosis) : On the other hand, PP2 , a Src tyrosine kinase inhibitor, also inhibited AII induced ERK1/2 and JNK activation, but its effect on ERK1/2 was less pronounced than that of olmesartan
Sim et al., Korean J Parasitol 2010 : Moreover, genistein and PP2 blocked the phosphorylation of ERK and p38 MAPK in neutrophils induced by E. histolytica
Zhang et al., J Cell Biochem 2013 : PP2 reduced the glutamate release from BDNF stimulated cortical neurons ( P? < ?0.05 ) and inhibited the phosphorylation levels of TrkB and PLC-?1 ( P? < ?0.05 ). However, PP2 had no effect on the phosphorylation levels of Erk1/2 or Akt ( P? > ?0.05 )
Shahidullah et al., Am J Physiol Cell Physiol 2013 : PP2 and the ERK inhibitor U0126 prevented robust ERK1/2 activation in cells exposed to DIDS or subjected to pHi reduction, but U0126 did not prevent SFK activation or the Na-K-ATPase activity response
Sunahori et al., J Biol Chem 2013 (Lupus Erythematosus, Systemic) : Similarly, in SLE T-cells, suppression of PP2Ac resulted in increased MEK/ERK phosphorylation, enhanced DNMT1 expression and suppressed expression of the methylation-sensitive CD70 gene ... We show that both chemical suppression and siRNA silencing of PP2Ac in T-cells resulted in sustained phosphorylation of MEK and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin