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Overexpression of PKM , a dominant interfering form of Pyk2, in NIH 3T3 cells results in a strong inhibition of the IFN-gamma induced activation of Erk2 , serine phosphorylation of Stat1 and Stat1 dependent gene transcription
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ERK1/2 dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect