Gene interactions and pathways from curated databases and text-mining

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EPHB2 — SLC2A4

Text-mined interactions from Literome

Berti et al., Mol Cell Endocrinol 1999 : PD98059, an ERK2 kinase-1 inhibitor, and wortmannin, an inhibitor of phosphatidylinositol 3-kinase blocked the leptin induced increase in glucose uptake and GLUT4 recruitment to the cell surface
Chen et al., J Biol Chem 2002 : Similarly, in L6 myotubes, ( a ) AICAR activated PYK2, ERK, PLD, and aPKCs ; ( b ) effects of AICAR on ERK were inhibited by genistein, PD98059, and expression of dominant negative PYK2 ; ( c ) effects of AICAR on PLD were inhibited by MEK1 inhibitor UO126 ; ( d ) effects of AICAR on aPKCs were inhibited by genistein, PD98059, 1-butanol, and expression of dominant negative forms of PYK2, GRB2, SOS, RAS, RAF, and ERK; and (e) effects of AICAR on 2DOG uptake/GLUT4 translocation were inhibited by genistein, PD98059, UO126, 1-butanol, cell-permeable myristoylated PKC-zeta pseudosubstrate, and expression of kinase-inactive RAF, ERK , and PKC-zeta