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IFNG — LPL
Text-mined interactions from Literome
Tengku-Muhammad et al., Cytokine 1999
:
We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin ( IL-1 ) and IL-11 was sensitive to herbimycin A, with the
effect of LPS,
interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on
LPL activity being sensitive to both herbimycin A and wortmannin ... The action of the inhibitors on the
IFN-gamma dependent reduction of
LPL activity was mediated at the level of LPL mRNA metabolism, with translational and/or post-translational levels of regulation being involved in the action of all the other mediators tested
Hughes et al., J Biol Chem 2002
:
We have shown previously that macrophage
lipoprotein lipase expression is
suppressed by
interferon-gamma (IFN-gamma) at the transcriptional level
Harris et al., Cell Signal 2008
:
The
interferon-gamma mediated
inhibition of
lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase mediated regulation of transcription factors Sp1 and Sp3 ... In the present study, we have investigated the signalling pathways that impact on the
IFN-gamma mediated regulation of Sp1/Sp3 binding and
LPL gene transcription in macrophages ... The
IFN-gamma mediated
inhibition of
LPL promoter activity was prevented by expression of dominant negative forms of casein kinase 2 ( CK2 ) and protein kinase B (PKB), a key downstream component of the phosphoinositide-3-kinase (PI3K) pathway ... Taken together, these results suggest a key role for CK2 and PI3K signalling pathways in the
IFN-gamma mediated inhibition of macrophage
LPL gene transcription through the regulation of Sp1/Sp3 binding
Jonasson et al., Biochim Biophys Acta 1990
:
Interferon-gamma inhibits
lipoprotein lipase in human monocyte derived macrophages ... Recombinant
IFN-gamma caused a profound decrease in macrophage
LPL secretion ... The data indicate that
IFN-gamma is
inhibiting macrophage
LPL at least in part via a reduction of LPL synthesis