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IFNG — TCF25

Text-mined interactions from Literome

Stephanou et al., Gene Expr 1999 : In addition, interferon-gamma (IFN-gamma) treatment increases the levels of Hsp70 and Hsp90 and also enhances the activity of the Hsp70 and Hsp90beta promoters with these effects being dependent on activation of the STAT-1 transcription factor by IFN-gamma
Yim et al., J Interferon Cytokine Res 1999 (Melanoma, Experimental) : IRF-2 is a nuclear transcription factor induced by IFN-gamma that represses numerous IFN-inducible genes, including genes that regulate cell growth, in opposition to the transcriptional activator IRF-1
Clavell et al., J Pediatr Gastroenterol Nutr 2000 (Colitis, Ulcerative...) : The transcription factor , interferon regulatory factor (IRF)-1, is stimulated by interferon-gamma and regulates the expression of several genes implicated in the pathogenesis of inflammatory bowel disease, including interleukin-6, major histocompatibility complex class II molecules, and inducible nitric oxide synthase
Crespo et al., Biochem J 2000 : A 2 -- 4 h pretreatment with LPS leads to a dramatic reduction in the IFN-gamma induced DNA binding of the transcription factor , signal transducer and activator of transcription 1 alpha ( STAT1 alpha )
Erkel et al., FEBS Lett 2000 : Studies on the mode of action of the compound revealed that the inhibition of the NF-kappaB dependent pathway is due to the stabilization of the IkappaB protein and the inhibition of the IFN-gamma dependent signaling is caused by an inhibition of the phosphorylation of the STAT1alpha transcription factor
Roy et al., Proc Natl Acad Sci U S A 2002 (MAP Kinase Signaling System) : MEKK1 plays a critical role in activating the transcription factor C/EBP-beta dependent gene expression in response to IFN-gamma
Kanda et al., J Invest Dermatol 2002 : Interferon stimulated response element and two nuclear factor-kappaB sites on interferon induced protein of 10 kDa promoter were responsible for the enhancement by substance P. Substance P alone enhanced transcriptional activity and transcription factor binding through the two nuclear factor-kappaB sites, whereas it did not alter interferon-gamma induced transcriptional activity and transcription factor binding through interferon stimulated response element
Ghoreschi et al., J Mol Med (Berl) 2003 (Psoriasis) : STAT1 activation by IFN-gamma is followed by T-bet activation, a master transcription factor for Th1 lymphocytes
Peng et al., Cancer Res 2004 (Adenocarcinoma...) : The T-box transcription factor T-bet ( Tbx21 ) plays a critical role in the development of type 1 helper T cells and is essential for the production of IFN-gamma
Navarro et al., J Interferon Cytokine Res 2003 : The rates of transcription of many of the genes encoding these RNAs are enhanced by IFN-gamma mediated activation of the Stat1 transcription factor that is tyrosine phosphorylated and translocates to the nucleus, where it binds enhancers present in IFN stimulated genes ( ISGs )
Qiao et al., J Immunol 2004 : Host defense against Mycobacterium tuberculosis requires the cytokine IFN-gamma and IFN regulatory factor 1 (IRF-1), a transcription factor that is induced to high levels by IFN-gamma
Lametschwandtner et al., J Allergy Clin Immunol 2004 (Dermatitis, Atopic) : The transcription factor T-bet mediates IFN-gamma production by T ( H ) 1 cells and suppresses T ( H ) 2 cytokine production when ectopically expressed in polarized murine T ( H ) 2 cells
Casal et al., Neurosci Res 2004 (Translocation, Genetic) : Abeta 25/35 alone did not induce NF-kappaB activation, but Abeta 25/35 plus IFN-gamma induced the activation of the transcription factor in the mixed and pure microglial cultures, although not in pure astroglia
Rugeles et al., Braz J Med Biol Res 2004 (Mycobacterium Infections...) : The expression of the STAT-1 molecule was similar in patients and healthy controls ; however, when the phosphorylation of this transcription factor in response to IFN-gamma activation was evaluated by Western blot, a significant lower signal was evident in one patient
Zhou et al., Exp Mol Pathol 2005 : The discovery that the BCL-6 transcription factor is inducible by IFN-gamma may help explain some of the postulated biological roles of BCL-6 in T cell development and differentiation, and help explain the Th2 biased phenotype of BCL-6-deficient mice
Song et al., J Biol Chem 2005 : IFN-gamma induced ERK1/2 phosphorylation and subsequently the transcription factor early gene response 1, which in turn up-regulated p35 expression and increased cyclin dependent kinase 5 (Cdk5) activity
Akahoshi et al., Hum Genet 2005 (Asthma...) : T-bet, a Th1-specific transcription factor of T-box family, has been found to control interferon-gamma (IFN-gamma) expression in T cells
Sullivan et al., J Immunol 2005 (Genetic Predisposition to Disease...) : Considerable work has demonstrated that the transcription factor , T-bet, is required for IFN-gamma expression and fundamental to the generation of type 1 immunity in multiple cell types
Park et al., J Immunol 2005 : TGF-beta1 inhibits Th1 development in part by suppressing the expression of T-bet, an IFN-gamma induced transcription factor that promotes Th1 differentiation, but how TGF-beta1 suppresses T-bet is not known
Wang et al., J Clin Invest 2006 (Arthritis, Experimental) : The transcription factor T-bet ( Tbx21 ) plays a major role in adaptive immunity and is required for optimal IFN-gamma production by DCs
Negishi et al., Proc Natl Acad Sci U S A 2006 : Evidence for licensing of IFN-gamma induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor dependent gene induction program
Karpuzoglu et al., Mol Immunol 2007 : IFN-gamma inducing transcription factor , T-bet is upregulated by estrogen in murine splenocytes : role of IL-27 but not IL-12
Becknell et al., Blood 2007 : Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine activated natural killer cells ... Here, we investigate the role of the Hlx transcription factor in IFN-gamma production by NK cells
Umegaki et al., J Invest Dermatol 2007 : We then demonstrated that KPNA2 physically bound to IFN regulatory factor-1 (IRF-1), a transcription factor induced by IFN-gamma , and induced nuclear translocation of IRF-1 in NHEKs
Chen et al., J Immunol 2007 : Retroviral transduction of activated gammadelta T cells from both wild-type and T-bet-deficient mice with a dominant negative form of Eomes significantly reduced IFN-gamma production, indicating a critical role for this transcription factor in mediating IFN-gamma production by gammadelta T cells in a T-bet independent manner
Schedel et al., Am J Respir Crit Care Med 2008 (Genetic Predisposition to Disease...) : Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding, IRF-1 gene expression, and IFN-gamma regulation
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 : [ Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets ]
Bluyssen et al., Proc Natl Acad Sci U S A 1995 : Induction is due to activation of a multimeric transcription factor , interferon stimulated gene factor 3 ( ISGF3 ), which is activated by IFN alpha/beta but not by IFN gamma
Guyer et al., J Immunol 1995 : IFN-gamma induces a p91/Stat1 alpha related transcription factor with distinct activation and binding properties
Sato et al., Blood 1995 : Interferon (IFN) regulatory factor-1 ( IRF-1 ) is a major transcription factor induced not only by IFN-gamma but also by other cytokines including tumor necrosis factor-alpha (TNF-alpha)
Zhang et al., Proc Natl Acad Sci U S A 1996 (Osteosarcoma) : Interferon gamma (IFN-gamma) induces rapid tyrosine phosphorylation of the latent cytoplasmic transcription factor , Stat1, which then forms homodimers, translocates to the nucleus and participates in IFN-gamma induced transcription
Spink et al., J Biol Chem 1997 : Transcriptional activation of the gene is dependent on the interferon-gamma induced transcription factor , interferon regulatory factor-1 (IRF-1)
Stancato et al., J Biol Chem 1998 : Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor
Stephanou et al., J Biol Chem 1999 : Here, we show that interferon-gamma (IFN-gamma) treatment increases the levels of Hsp-70 and Hsp-90 and also enhances the activity of the Hsp-70 and Hsp-90beta promoters with these effects being dependent on activation of the STAT-1 transcription factor by IFN-gamma
Wang et al., Invest Ophthalmol Vis Sci 1999 : To determine whether nuclear transcription factor-kappaB ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in response to interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), or interferon-gamma (IFN-gamma) alone or in combination and if so, whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor, MG-132, which inhibits the degradation of I kappaB, an NF-kappaB inhibitor, thereby preventing nuclear translocation of NF-kappaB