◀ Back to PAK1
ARHGEF7 — PAK1
Pathways - manually collected, often from reviews:
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
utrophin (UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
utrophin (UTRN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
→
None
(modification, activates)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
→
None
(modification, activates)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
cortactin (CTTN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
cortactin (CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1)
→
Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
KEGG Regulation of actin cytoskeleton:
PAK1/PAK2/PAK3/PAK4/PAK6/PAK7
→
ARHGEF6/ARHGEF7
(protein-protein, phosphorylation)
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
PAK1/Aurora A complex (PAK1-AURKA)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
Aurora A (AURKA)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
GIT1/betaPIX complex (GIT1-ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
PAK1/Aurora A complex (PAK1-AURKA)
→
GIT1/betaPIX complex (GIT1-ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
RAC1/GTP complex (RAC1)
→
PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1)
(modification, activates)
Brown et al., Mol Biol Cell 2002
Evidence: mutant phenotype, assay
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN)
→
PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1)
(modification, collaborate)
Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN)
→
FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN)
(modification, collaborate)
Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1)
→
FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN)
(modification, collaborate)
Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
→
PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1)
(modification, activates)
Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Yu et al., Mol Biol Cell 2009
Evidence: mutant phenotype, assay
-
NCI Pathway Database Aurora A signaling:
PAK1 (PAK1)
→
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
PAK1 (PAK1)
→
betaPIX (ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1 (GIT1)
→
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
betaPIX (ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
Reactome Reaction:
PAK1
→
ARHGEF7
(indirect_complex)
Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
-
Reactome Reaction:
PAK1
→
ARHGEF7
(reaction)
Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
-
WikiPathways Regulation of Actin Cytoskeleton:
PAK1/PAK2/PAK3/PAK4/PAK6/PAK7
→
ARHGEF6/ARHGEF7
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PAK1
—
ARHGEF7
(physical association, affinity chromatography technology)
Varjosalo et al., Nat Methods 2013
-
IRef Biogrid Interaction:
PAK1
—
ARHGEF7
(physical association, affinity chromatography technology)
Ku et al., EMBO J 2001*
-
IRef Biogrid Interaction:
PAK1
—
ARHGEF7
(physical association, affinity chromatography technology)
Schmidt et al., Oncogene 2006
-
IRef Biogrid Interaction:
PAK1
—
ARHGEF7
(direct interaction, two hybrid)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Hprd Interaction:
Complex of 17 proteins
Brown et al., Mol Biol Cell 2002
-
IRef Hprd Interaction:
ARHGEF7
—
PAK1
(in vitro)
Turner et al., J Cell Biol 1999, Ku et al., EMBO J 2001*, Mott et al., Biochemistry 2005*
-
IRef Hprd Interaction:
ARHGEF7
—
PAK1
(in vivo)
Turner et al., J Cell Biol 1999, Ku et al., EMBO J 2001*, Mott et al., Biochemistry 2005*
-
IRef Intact Interaction:
Complex of PAK1-NCK2-ARHGEF6-GIT1-PAK2-ARHGEF7-CDC42-FBXO28
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(direct interaction, nuclear magnetic resonance)
Mott et al., Biochemistry 2005*
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(direct interaction, classical fluorescence spectroscopy)
Mott et al., Biochemistry 2005*
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(physical association, anti bait coimmunoprecipitation)
Schmidt et al., Oncogene 2006
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(physical association, pull down)
ten Klooster et al., J Cell Biol 2006*
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(physical association, anti bait coimmunoprecipitation)
Frank et al., EMBO J 2006*
-
IRef Intact Interaction:
ARHGEF7
—
PAK1
(physical association, two hybrid pooling approach)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Ophid Interaction:
ARHGEF7
—
PAK1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lee et al., J Biol Chem 2001
:
This betaPix induced p38 activation was blocked by coexpression of dominant negative Cdc42/Rac or kinase-inactive PAK, indicating that the effect of
betaPix on p38 is exerted through the Cdc42/Rac-PAK pathway and
requires PAK kinase activity
Feng et al., J Biol Chem 2002
:
Three members of the Cool/Pix family have shown distinct regulatory activities : ( i ) p50 ( Cool-1 ) inhibits Cdc42/Rac stimulated PAK activity, ( ii ) p85 ( Cool-1 )
/beta-Pix has a permissive effect on Cdc42/Rac stimulated activity, and ( iii ) p90 ( Cool-2 ) /alpha-Pix strongly
activates PAK ... Rather, an 18-amino acid region, designated T1, that is present in the Cool-1 proteins, but missing in Cool-2, is essential for controlling the
regulation of
PAK activity by
Cool-1/beta-Pix in vivo
Zhao et al., Mol Cell 2005
:
In vivo PAK activation causes an accumulation of activated Aurora-A ; conversely, when
betaPIX is depleted or
PAK is
inhibited , there is a delay in centrosome maturation
ten Klooster et al., J Cell Biol 2006
:
Finally, using cells deficient for the beta-Pix binding kinase Pak1, we show that
Pak1 regulates the
Rac1-beta-Pix interaction and controls cell spreading and adhesion induced Rac1 activation