Gene interactions and pathways from curated databases and text-mining

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ARHGEF7 — PAK1

Pathways - manually collected, often from reviews:

  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → utrophin (UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: utrophin (UTRN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → cortactin (CTTN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: cortactin (CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • KEGG Regulation of actin cytoskeleton: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → ARHGEF6/ARHGEF7 (protein-protein, phosphorylation)
  • NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → PAK1/Aurora A complex (PAK1-AURKA) (modification, collaborate)
    Zhao et al., Mol Cell 2005*
    Evidence: physical interaction
  • NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → Aurora A (AURKA) (modification, collaborate) Zhao et al., Mol Cell 2005*
    Evidence: physical interaction
  • NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → GIT1/betaPIX complex (GIT1-ARHGEF7) (modification, collaborate)
    Zhao et al., Mol Cell 2005*
    Evidence: physical interaction
  • NCI Pathway Database Aurora A signaling: PAK1/Aurora A complex (PAK1-AURKA) → GIT1/betaPIX complex (GIT1-ARHGEF7) (modification, collaborate)
    Zhao et al., Mol Cell 2005*
    Evidence: physical interaction
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: RAC1/GTP complex (RAC1) → PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) (modification, activates)
    Brown et al., Mol Biol Cell 2002
    Evidence: mutant phenotype, assay
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN) → PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) (modification, collaborate)
    Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
    Evidence: physical interaction
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN) → FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN) (modification, collaborate)
    Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
    Evidence: physical interaction
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) → FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN) (modification, collaborate)
    Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
    Evidence: physical interaction
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN) → PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) (modification, activates)
    Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Yu et al., Mol Biol Cell 2009
    Evidence: mutant phenotype, assay
  • NCI Pathway Database Aurora A signaling: PAK1 (PAK1) → GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) (modification, collaborate)
    Zhao et al., Mol Cell 2005*
    Evidence: assay, physical interaction
  • NCI Pathway Database Aurora A signaling: PAK1 (PAK1) → betaPIX (ARHGEF7) (modification, collaborate) Zhao et al., Mol Cell 2005*
    Evidence: assay, physical interaction
  • NCI Pathway Database Aurora A signaling: GIT1 (GIT1) → GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) (modification, collaborate)
    Zhao et al., Mol Cell 2005*
    Evidence: assay, physical interaction
  • NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → betaPIX (ARHGEF7) (modification, collaborate) Zhao et al., Mol Cell 2005*
    Evidence: assay, physical interaction
  • Reactome Reaction: PAK1 → ARHGEF7 (indirect_complex) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
  • Reactome Reaction: PAK1 → ARHGEF7 (reaction) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
  • WikiPathways Regulation of Actin Cytoskeleton: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → ARHGEF6/ARHGEF7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., J Biol Chem 2001 : This betaPix induced p38 activation was blocked by coexpression of dominant negative Cdc42/Rac or kinase-inactive PAK, indicating that the effect of betaPix on p38 is exerted through the Cdc42/Rac-PAK pathway and requires PAK kinase activity
Feng et al., J Biol Chem 2002 : Three members of the Cool/Pix family have shown distinct regulatory activities : ( i ) p50 ( Cool-1 ) inhibits Cdc42/Rac stimulated PAK activity, ( ii ) p85 ( Cool-1 ) /beta-Pix has a permissive effect on Cdc42/Rac stimulated activity, and ( iii ) p90 ( Cool-2 ) /alpha-Pix strongly activates PAK ... Rather, an 18-amino acid region, designated T1, that is present in the Cool-1 proteins, but missing in Cool-2, is essential for controlling the regulation of PAK activity by Cool-1/beta-Pix in vivo
Zhao et al., Mol Cell 2005 : In vivo PAK activation causes an accumulation of activated Aurora-A ; conversely, when betaPIX is depleted or PAK is inhibited , there is a delay in centrosome maturation
ten Klooster et al., J Cell Biol 2006 : Finally, using cells deficient for the beta-Pix binding kinase Pak1, we show that Pak1 regulates the Rac1-beta-Pix interaction and controls cell spreading and adhesion induced Rac1 activation