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FOXO1 — PDK1
Text-mined interactions from Literome
Rena et al., EMBO J 2002
:
IGF-1 stimulates the phosphorylation of Thr24, Ser256, Ser319, Ser322 and Ser325 in embryonic stem ( ES ) cells, but not in PDK1-/- ES cells, providing genetic evidence that
PDK1 ( the upstream activator of PKB ) is
required for the phosphorylation of
FKHR in mammalian cells
Kawano et al., Diabetes 2012
(Insulin Resistance...) :
Thus,
Pdk1 regulated macrophage infiltration by inhibiting
Foxo1 induced Ccr2 expression