Gene interactions and pathways from curated databases and text-mining

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BBC3 — BCL2L1

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Direct p53 effectors: PUMA/BCL2 subfamily complex (BBC3-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) → p53 (TP53) (modification, collaborate) Chipuk et al., Science 2005
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database Direct p53 effectors: PUMA/BCL2 subfamily complex (BBC3-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) → PUMA (BBC3) (modification, collaborate) Chipuk et al., Science 2005
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database Direct p53 effectors: PUMA/BCL2 subfamily complex (BBC3-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) → p53/BCL2 subfamily complex (TP53-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) (modification, collaborate)
    Chipuk et al., Science 2005
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database Direct p53 effectors: PUMA (BBC3) → p53/BCL2 subfamily complex (TP53-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) (modification, collaborate)
    Chipuk et al., Science 2005
    Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *