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GSK3B — NOTCH3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Espinosa et al., J Biol Chem 2003
:
Consistent with this,
GSK-3 beta inhibits the transcriptional activation of
Notch target genes both in vitro and in vivo, whereas lithium chloride treatment or Wnt-1 overexpression that results in GSK-3 beta inhibition leads to the up-regulation of the Hes-1 promoter ... Together, our results suggest that cross-talk between Notch and Wnt pathways may be partially mediated by specific regulation of
GSK-3 beta dependent
Notch phosphorylation
Guha et al., Basic Res Cardiol 2011
(Neointima) :
Glycogen synthase kinase 3 beta positively
regulates Notch signaling in vascular smooth muscle cells : role in cell proliferation and survival