Gene interactions and pathways from curated databases and text-mining

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NOTCH3 — SMAD5

Text-mined interactions from Literome

Kennard et al., J Biol Chem 2008 : The repression of Notch3 was mediated by SMAD activity and p38 mitogen activated protein ( MAP ) kinase, whereas analysis of the Hes1 promoter revealed direct activation by Smad2 but not Smad3
Quillien et al., Development 2011 : However, the activation of Notch dependent transcription does not require a canonical Smad5-DNA interaction