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Yin et al., Cancer Res 2006
(Hyperplasia) :
Furthermore, depletion of hPar1 by small interfering RNA ( siRNA ) vectors markedly inhibited
PAR1 induced
Wnt-4
Turm et al., Communicative & integrative biology 2010
:
Similarly,
PAR(1) induced placenta cytotrophoblast physiological invasion process was not
affected by inhibiting
Wnt , but was abrogated by siRNA-DvL. we propose that DvL serves as a central mediator protein that links classical GPCRs to ß-catenin stabilization in both pathological ( tumor ) and physiological ( placenta ) invasion processes