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JUN — TGFB3
Text-mined interactions from Literome
Wong et al., Mol Cell Biol 1999
:
Smad3-Smad4 and AP-1 complexes synergize in transcriptional
activation of the
c-Jun promoter by
transforming growth factor beta
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Dennler et al., J Biol Chem 2000
:
c-Jun inhibits
transforming growth factor beta mediated transcription by repressing Smad3 transcriptional activity
Wang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001
:
Heat shock
induces elevated expression of hsp,
c-Jun , CLK-1 gene while decreases expression of integrin alpha-4 and
transforming growth factor beta
Matsuzaki et al., Hepatology 2007
(Carcinoma, Hepatocellular...) :
Conversely,
transforming growth factor beta ( TGF-beta )
activates not only TGF-beta type I receptor ( TbetaRI ) but also
c-Jun N-terminal kinase (JNK) , which convert the mediator Smad3 into two distinctive phosphoisoforms : C-terminally phosphorylated Smad3 ( pSmad3C ) and linker phosphorylated Smad3 ( pSmad3L )
Markovics et al., J Biol Chem 2010
(Inflammation) :
Transcription of the
transforming growth factor beta activating integrin beta8 subunit is
regulated by SP3,
AP-1 , and the p38 pathway