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EPHB2 — NCK1

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHB forward signaling: Ephrin B1/EPHB1-2/NCK1 complex (EFNB1-EPHB1_EPHB2-NCK1) → MAP4K4 (MAP4K4) (modification, activates) Becker et al., Mol Cell Biol 2000
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B1/EPHB1-2/NCK1 complex (EFNB1-EPHB1_EPHB2-NCK1) → Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) (modification, collaborate)
  Stein et al., J Biol Chem 1998*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B1/EPHB1-2/NCK1 complex (EFNB1-EPHB1_EPHB2-NCK1) → NCK1 (NCK1) (modification, collaborate) Stein et al., J Biol Chem 1998*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → NCK1 (NCK1) (modification, collaborate) Stein et al., J Biol Chem 1998*
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: NCK1 — EPHB2 (in vivo) Holland et al., EMBO J 1997
• IRef Hprd Interaction: NCK1 — EPHB2 (in vitro) Holland et al., EMBO J 1997
• IRef Ophid Interaction: NCK1 — EPHB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: NCK1 — EPHB2 (aggregation, confirmational text mining) Holland et al., EMBO J 1997

Text-mined interactions from Literome

Schmitz et al., J Biol Chem 2001 : Overexpression of dominant negative Nck in Chinese hamster ovary ( CHO ) cells, stably expressing the AngII type I receptor ( CHO-AT1 ), inhibited both PAK and JNK activation by AngII, whereas it did not affect ERK1/2
Tanaka et al., Mol Cell Biol 1995 : The Crk-1 SH2 mutant was less effective, while Nck SH2 and SH3 mutants had little or no effect on Erk activation
Gupta et al., Oncogene 1998 : We also show that dominant negative mutants of Grb2 and Nck can inhibit eFGF induced Erk1 activation in Xenopus animal caps, and that targeting the first two SH3 domains of Nck to the membrane can activate Erk1 in the absence of eFGF ... Furthermore, combinations of the dominant negative Grb2 mutants with the inhibitory Nck mutant synergistically inhibited Erk1 activation by eFGF in Xenopus animal caps, suggesting that the dominant negative Nck and Grb2 mutants inhibit Erk1 activation by binding to different proteins