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CASP3 — IFNB1
Text-mined interactions from Literome
Scheel-Toellner et al., Eur J Immunol 1999
:
IFN-beta also
inhibited caspase 3 and the proteolytic activation of PKC-delta
Morrison et al., Oncogene 2002
(Ovarian Neoplasms) :
Both
IFN-beta and radiation
induced caspase 8
Saito et al., J Neurooncol 2004
(Brain Neoplasms...) :
Collectively, these findings indicate that
IFN-beta induced apoptosis in human glioma cells through activation of
caspase-7 and activation of DNase-gamma
Takada et al., Exp Cell Res 2005
(Lymphoma, B-Cell) :
The
IFN-beta induced up-regulation of CD95 together with
caspase-8 activation was also abrogated in the dnJNK1 cells while it was further enhanced in the MKK7-JNK1 cells
Zhou et al., J Interferon Cytokine Res 2008
(Leukemia) :
Consistent with these results, treatment with IFN-gamma, but not IFN-alpha or
IFN-beta ,
induced the release of cytochrome c, activation of
caspase-3 , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ), a well characterized caspase-3 substrate
Kawaguchi et al., Int J Cancer 2009
(Prostatic Neoplasms) :
Produced
IFN-alpha and -beta enhanced
caspase 8 expression via Janus kinases/Signal Transducers and Activators of Transcription pathway, activated caspase 3 and induced apoptosis in cancer cells
Yen et al., Blood 2009
(Inflammation...) :
Interferon beta induces mature dendritic cell apoptosis through
caspase-11/caspase-3 activation
Santic et al., Cell Microbiol 2010
(Tularemia) :
Initial sensing of F. tularensis in the cytosol triggers IRF-3 dependent
IFN-beta secretion, type I IFNR dependent signalling,
activation of the inflammasome mediated by
caspase-1 , and a pro-inflammatory response, which is suppressed by triggering of SHIP
Kamiya et al., J Interferon Cytokine Res 2010
(Melanoma) :
To characterize the signaling pathway involved in IFN-beta induced apoptosis, we analyzed the biological
effects of
IFN-beta on the cell death and
caspase activation of melanoma cells ... IFN-sensitive cell lines, MM418, SK-mel-23, and SK-mel-118, showed increased apoptotic populations correlated with the
activation of caspase-2 and
caspase-3 by
IFN-beta