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PTGS2 — TLR9

Text-mined interactions from Literome

Yeo et al., J Biol Chem 2003 : Conclusively, these results demonstrate that endosomal DNA processing and TLR9/MyD88 dependent activation of NF-kappaB and p38 are required for transcriptional regulation of Cox-2 expression induced by CpG DNA, and suggest that interleukin-1 receptor associated kinase and/or TRAF6 may be a diverging point for NF-kappaB activation in response to CpG DNA in RAW264.7 cells
Chang et al., Mol Pharmacol 2004 : Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src dependent nuclear factor-kappaB activation
Di et al., Mol Biol Rep 2010 (Prostatic Neoplasms) : Since cyclooxygenase 2 (COX-2), frequently overexpressed in multiple tumor types including prostate cancer, is a causal factor for tumor development, invasion and metastasis, an interesting question is raised whether TLR9 regulates COX-2 expression in prostate cancer cells ... The regulatory role of NF-kappaB in TLR9 mediated COX-2 expression was also investigated
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach
Bernard et al., J Immunol 2010 : We hypothesized that Cox-2 is induced by TLR activation and is necessary for optimal AMP production, and that inhibitors of Cox-2 may therefore inhibit antimicrobial action
Joseph et al., Biol Reprod 2013 (Inflammation) : Previously we reported the expression of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), also known as cyclooxygenase 2 (COX-2), in human vaginal cells in response to toll-like receptor ( TLR ) ligands and other proinflammatory stimuli