Hsieh et al., Cancer Res 1999
:
Resveratrol increases nitric oxide synthase , induces accumulation of p53 and p21 ( WAF1/CIP1 ), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2
Kibbe et al., J Vasc Surg 2000
:
NO exposure by the NO-donor SNAP or iNOS gene transfer induced a dose- and time dependent increase in p21 protein expression in RASMCs
Kibbe et al., J Vasc Surg 2000
(Hyperplasia) :
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate