Gene interactions and pathways from curated databases and text-mining

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EGF — ERCC1

Text-mined interactions from Literome

Yacoub et al., Radiat Res 2003 (Adenocarcinoma...) : Although the EGFR inhibitor tyrphostin ( AG-1478 ) and the MEK inhibitor PD90859 both attenuated EGF induced levels of the ERCC1 and XRCC1 protein, PD98059 blocked the induction of ERCC1 and XRCC1 by radiation more effectively in both cell lines
Andrieux et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : GATA-1 is essential in EGF mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells ... Moreover, EGF mediated activation of ERCC1 was specifically inhibited by either the addition of U0126, a MEK/ERK inhibitor or small interfering RNA mediated knockdown of ERK2
Wang et al., Anticancer Drugs 2013 (Adenocarcinoma...) : In contrast, epidermal growth factor induced increase in ERCC1 protein levels was shown to rescue cell viability upon 8-c treatment