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EGF — GSK3B

Text-mined interactions from Literome

Ma et al., Biochem Pharmacol 2005 : Ethanol inhibited EGF induced EGFR autophosphorylation, phosphorylation of ERK as well as Akt and its substrate GSK-3beta , and subsequently blocked EGF stimulated AP-1 activation in B82L cells
Xu et al., J Biol Chem 2007 : Down-regulation of endogenous XB130 with siRNA reduced c-Src activity, IL-8 production, EGF induced phosphorylation of Akt and GSK3beta , and altered cell cycles in human lung epithelial cells
Nakashima et al., Int J Oncol 2010 (Colonic Neoplasms...) : Interestingly, EGF induced phosphorylation of both Akt and glycogen synthase kinase-3beta ( GSK-3beta ), but not p44/p42 mitogen activated protein ( MAP ) kinase, were dose-dependently enhanced when the cells were pretreated with Y27632 or fasudil, another Rho-kinase inhibitor
Edouard et al., Mol Cell Biol 2010 (LEOPARD Syndrome) : Functional effects of PTPN11 ( SHP2 ) mutations causing LEOPARD syndrome on epidermal growth factor induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling ... We report here that fibroblasts isolated from LS patients displayed stronger epidermal growth factor (EGF) induced phosphorylation of both AKT and glycogen synthase kinase 3beta ( GSK-3beta ) than fibroblasts from control patients ... In conclusion, SHP2 mutations causing LS facilitate EGF induced PI3K/AKT/GSK-3beta stimulation through impaired GAB1 dephosphorylation, resulting in deregulation of a novel signaling pathway that could be involved in LS pathology
Zaouali et al., Liver Transpl 2010 (Disease Models, Animal...) : When AKT was inhibited, the effects of EGF and IGF-I on GSK3(beta) , PPAR gamma, hepatic injury and function disappeared
Eldar-Finkelman et al., J Biol Chem 1995 : EGF induced a rapid decrease in GSK-3 beta activity ( 50 % ) in control and S222E cells ; however, only 25 and 10 % inhibition in GSK-3 beta activity was observed in cell lines expressing the dominant negative mutants K97A and S222A, respectively, suggesting that inhibition of GSK-3 was partially blocked in these cells
Saito et al., Biochem J 1994 : EGF stimulation of A431 cells inhibited GSK3 alpha and GSK3 beta to a similar extent, and inhibition was accompanied by phosphorylation of the tryptic peptides containing the serine residues phosphorylated in vitro by p70 S6 kinase or MAP kinase activated protein ( MAPKAP ) kinase-1 beta ( also termed Rsk-2 )