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FST — SMAD3
Text-mined interactions from Literome
Stove et al., Oncogene 2004
(Melanoma) :
Secretion of
follistatin , either native or after retroviral transduction, efficiently
prevented Smad activation or activation of an activin-responsive luciferase reporter construct
Blount et al., J Biol Chem 2009
(Blepharoptosis) :
FoxL2 and
Smad3 coordinately
regulate follistatin gene transcription
Winbanks et al., J Cell Biol 2012
(Hypertrophy) :
Importantly, the regulation of Smad3- and mTOR dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate
Smad3 and mTOR signaling and that is itself
inhibited by
follistatin
McTavish et al., Mol Cell Endocrinol 2013
(Granulosa Cell Tumor) :
In the pituitary, FOXL2 and
Smad3 coordinately
regulate activin stimulation of
follistatin transcription ... We show that in primary granulosa cells, GDF-9 and activin increase
Smad3 mediated
follistatin transcription ... This study highlights that FOXL2 negatively regulates
follistatin expression within the ovary, and that the pathogenesis of FOXL2 ( C134W ) may
involve an altered interaction with
Smad3