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CD40LG — IL2

Text-mined interactions from Literome

Skov et al., J Immunol 2000 : IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells
Yi et al., J Immunol 2000 (Lupus Erythematosus, Systemic...) : The sustained CD40L expression in lupus T cells did not correlate with memory status or Th deviation, and was relatively independent of IL-2 or other autocrine or paracrine signals via CD28 or CTLA-4
McDowell et al., Infect Immun 2002 : Leishmania priming of human dendritic cells for CD40 ligand induced interleukin-12p70 secretion is strain and species dependent
McDyer et al., J Immunol 2002 : IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells : disruption of both IL-12 dependent and -independent pathways of IFN-gamma production ... We found CD40L expression to be biphasic with an early ( 6 h ) peak that is CD28/IL-2 independent, but a later peak ( 48 h ) being CD28/IL-2 dependent and inhibited by HAT
Möttönen et al., Arthritis Res 2002 (Arthritis, Rheumatoid) : Regulation of CD154 induced interleukin-12 production in synovial fluid macrophages
Skov et al., Blood 2003 (Autoimmune Diseases...) : HDAC-i thus inhibited interleukin 2 (IL-2) induced CD154 expression on effector T cells and constitutively expressed CD154 on various tumor cells, events that were not affected by cyclosporine
Wagner et al., Arterioscler Thromb Vasc Biol 2002 : One consequence of this statin dependent downregulation of CD40 expression was a decrease in CD40 ligand induced endothelial interleukin-12 expression
Yoshimoto et al., J Exp Med 2003 : NKT cells express high levels of IL-18 receptor ( R ) alpha chain and produce significant amounts of IL-4, IL-9, and IL-13, and induce CD40 ligand expression in response to IL-2 and IL-18 stimulation in vitro
Haynes et al., Immunol Rev 2005 : This improvement in cognate function of the aged effectors may be related to the enhancement of CD154 expression, which occurs on aged T cells in the presence of exogenous IL-2
Loskog et al., Clin Cancer Res 2005 (Carcinoma...) : CD40L stimulation of dendritic cells induces interleukin-12 expression that drives Th1 type of immune responses with activation of cytotoxic T cells
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2 , and IL-10 secretion
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Bihl et al., J Immunol 2010 (Leishmaniasis, Cutaneous) : We show that early IFN-gamma secretion by NK cells is controlled by IL-2 and IL-12 and is dependent on CD40/CD40L interaction
Ramsdell et al., J Immunol 1994 : We were unable to detect IL-2 or IL-4 production in response to CD40L , and Ab-blocking studies indicate that the mechanism of activation appears to involve IL-1 but is independent of IL-2, IL-4, and IL-7
Grabstein et al., J Immunol 1993 : The requirement for both CD40 ligand and IL-2 for induction of Ag-specific antibody responses was mediated , in part, by the induction of B cell IL-2R expression by CD40 ligand
Fanslow et al., J Immunol 1994 : The presence of CD40L during suboptimal TCR stimulation resulted in increased expression of the activation Ags IL-2R alpha and CD69 and increased IL-2 production
Karmann et al., Eur J Immunol 1996 : Exogenous IL-2 can also increase CD40 ligand expression ... However, increased IL-2 secretion in the presence of EC can not fully account for endothelial induced CD40 ligand up-regulation as ( 1 ) the effect of exogenous IL-2 is greater at 24 h than at 6 h, whereas the opposite is true for EC ; ( 2 ) the effect of saturating levels of IL-2 is considerably smaller than that of EC ; and ( 3 ) blocking of IL-2 receptors does not fully inhibit endothelial effects on CD40 ligand expression
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Jaiswal et al., Int Immunol 1996 : Anti-CD3 in the absence of co-stimuli induced high CD40L expression but no IL-2 production and provision of co-stimulatory signals, although inducing large quantities of IL-2, did not increase CD40L expression ... In addition, low CD40L expression induced by antigen presented in the absence of accessory molecules was not enhanced by co-stimulation, although IL-2 was strongly up-regulated
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Bulfone-Paus et al., Cytokine 1997 : However, IL-2 upregulates CD30, TNF receptor type II and CD40L expression significantly stronger than IL-15