Gene interactions and pathways from curated databases and text-mining

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MAP3K1 — RAC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., Mol Endocrinol 2000 (Endometrial Neoplasms...) : The expression of wild-type MEKK1 and an active Rac1, which functions upstream of MEKK1, also increased the activity of the receptor while coexpression of dominant negative MEKK1 blocked the Rac1 induction, indicating that endogenous MEKK1 is capable of activating the receptor
Healy et al., Am J Physiol Cell Physiol 2008 : Our studies also indicate that Rac and, to a lesser extent, Cdc42 transactivate MEKK1 , which is, in turn, responsible for activation of mitogen activated protein kinase kinase 7 ( MKK7 )