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AR — FOXO1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FOXO1 → AR (directlyDecreases, AR Activity) Li et al., Mol Cell Biol 2003*
  Evidence: Recent studies suggested that the protection of cell apoptosis by AKT involves phosphorylation and inhibition of FKHR and related FOXO forkhead transcription factors Transcriptional analysis demonstrated that activation of the androgen receptor caused an inhibition of both wild-type FKHR and a mutant in which all three known AKT sites were mutated to alanines, showing that the repression is AKT independent
• NCI Pathway Database Regulation of Androgen receptor activity: FOXO1 (FOXO1) → AR/T-DHT complex (AR) (transcription, inhibits) Dong et al., Cancer Res 2006*
  Evidence: mutant phenotype
• NCI Pathway Database Regulation of Androgen receptor activity: T-DHT/AR/TIF2 complex (AR-NCOA2) → FOXO1 (FOXO1) (cell proliferation, activates) Fu et al., Mol Cell Biol 2003, Dong et al., Cancer Res 2006*, Wang et al., Mol Cell 2007
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AR — FOXO1 (direct interaction, two hybrid) Li et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: AR — FOXO1 (physical association, affinity chromatography technology) Li et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: AR — FOXO1 (direct interaction, far western blotting) Li et al., Mol Cell Biol 2003*
• IRef Hprd Interaction: AR — FOXO1 (in vivo) Li et al., Mol Cell Biol 2003*
• IRef Hprd Interaction: AR — FOXO1 (in vitro) Li et al., Mol Cell Biol 2003*
• IRef Intact Interaction: AR — FOXO1 (physical association, anti bait coimmunoprecipitation) Fan et al., J Biol Chem 2007*
• IRef Ophid Interaction: AR — FOXO1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: AR — FOXO1 (aggregation, confirmational text mining) Li et al., Mol Cell Biol 2003*

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2003 (Prostatic Neoplasms) : Transcriptional analysis demonstrated that activation of the androgen receptor caused an inhibition of both wild-type FKHR and a mutant in which all three known AKT sites were mutated to alanines, showing that the repression is AKT independent ... Further analysis demonstrated that the activated androgen receptor blocked FKHR 's DNA binding activity and impaired its ability to induce Fas ligand expression and prostate cancer cell apoptosis and cell cycle arrest
Ma et al., Mol Endocrinol 2009 : FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment