UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to PRKCI

PRKCI — RIPK2

Pathways - manually collected, often from reviews:

NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/TRKA complex (NTRK1-NGF) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, inhibits)
Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
Evidence: mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
Evidence: mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → Atypical PKCs (PRKCI/PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: Atypical PKCs (PRKCI/PRKCZ) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: p62 (SQSTM1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species