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HLA-DRB1 — YY1
Text-mined interactions from Literome
Baritaki et al., Mol Cancer Ther 2007
(Neoplasms) :
DR5 luciferase reporter constructs and small interfering RNA against YY1 were used to determine the
role of
YY1 in
DR5 transcription
Huerta-Yepez et al., Nitric Oxide 2009
:
The
role of
YY1 in the transcriptional regulation of
DR5 was examined in cells treated with a DR5 luciferase reporter system ( pDR5 ) and two constructs, namely, the pDR5/-605 construct with a deletion of the putative YY1 DNA binding region ( -1224 to -605 ) and a construct pDR5-YY1 with a mutation of the YY1 DNA binding site ... The present findings demonstrate that
YY1 negatively
regulates DR5 transcription and expression and these correlated with resistance to TRAIL induced apoptosis
MartÃnez-Paniagua et al., Cell cycle (Georgetown, Tex.) 2011
:
Mcl-1 and
YY1 inhibition and
induction of
DR5 by the BH3-mimetic Obatoclax ( GX15-070 ) contribute in the sensitization of B-NHL cells to TRAIL apoptosis