UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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FKBP4 — IRF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: FKBP4 — IRF4 (physical association, affinity chromatography technology) Mamane et al., Immunity 2000 *
IRef Hprd Interaction: IRF4 — FKBP4 (in vivo) Mamane et al., Immunity 2000 *
IRef Hprd Interaction: IRF4 — FKBP4 (in vitro) Mamane et al., Immunity 2000 *
IRef Innatedb Interaction: IRF4 — FKBP4 (unknown, -) Mamane et al., Immunity 2000 *

Text-mined interactions from Literome

Mamane et al., Immunity 2000 : Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52
Collado-Romero et al., Journal of proteomics 2012 (Inflammation...) : According to this, we identified the up-regulation of FK506 binding protein 4 (FKBP4) , a negative regulator of the transcription factor IRF4 ( interferon regulatory factor 4 ), implicated in Th2 and Th17 response