◀ Back to STAT1
STAT1 — STAT2
Pathways - manually collected, often from reviews:
-
BioCarta ifn alpha signaling pathway:
p48 (ST13)
→
STAT1/STAT2/p48 complex (STAT2-STAT1-ST13)
(modification, collaborate)
-
BioCarta ifn alpha signaling pathway:
p48 (ST13)
→
STAT1/STAT2 (ISGF3-alpha) complex (STAT2-STAT1)
(modification, collaborate)
-
BioCarta ifn alpha signaling pathway:
STAT1/STAT2/p48 complex (STAT2-STAT1-ST13)
→
STAT1/STAT2 (ISGF3-alpha) complex (STAT2-STAT1)
(modification, collaborate)
-
BioCarta ifn alpha signaling pathway:
STAT1
→
STAT2
(modification, collaborate)
-
BioCarta ifn alpha signaling pathway:
STAT1
→
STAT1/STAT2 (ISGF3-alpha) complex (STAT2-STAT1)
(modification, collaborate)
-
BioCarta ifn alpha signaling pathway:
STAT2
→
STAT1/STAT2 (ISGF3-alpha) complex (STAT2-STAT1)
(modification, collaborate)
-
FastForward regulation:
STAT1, STAT2, IRF9
→
STAT2
(transcriptional regulation, increase)
Yan et al., Nucleic Acids Res 1995*
Evidence: DNABINDING, PROMACTIVITY
-
Reactome Reaction:
STAT1
→
STAT2
(direct_complex)
-
Reactome Reaction:
STAT1
→
STAT2
(reaction)
Mowen et al., Mol Cell Biol 2000, Wesoly et al., Acta biochimica Polonica 2007, Shuai et al., Cell 1994, Müller et al., Nature 1993, Li et al., J Biol Chem 1996
-
Reactome Reaction:
STAT2
→
STAT1
(direct_complex)
-
Reactome Reaction:
STAT1
→
STAT2
(indirect_complex)
You et al., Mol Cell Biol 1999, Mowen et al., Mol Cell Biol 2000, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Müller et al., Nature 1993
-
Reactome Reaction:
STAT2
→
STAT1
(indirect_complex)
You et al., Mol Cell Biol 1999, Mowen et al., Mol Cell Biol 2000, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Müller et al., Nature 1993
-
Reactome Reaction:
STAT2
→
STAT1
(reaction)
Mowen et al., Mol Cell Biol 2000, Wesoly et al., Acta biochimica Polonica 2007, Müller et al., Nature 1993, Li et al., J Biol Chem 1996
-
WikiPathways Type II interferon signaling (IFNG):
Complex of STAT2-STAT1-IRF9-IRF9
→
EIF2AK2
(activation)
-
WikiPathways Type II interferon signaling (IFNG):
Complex of STAT2-STAT1-IRF9-IRF9
→
CXCL10
(activation)
-
WikiPathways Type II interferon signaling (IFNG):
Complex of STAT2-STAT1-IRF9-IRF9
→
IFIT2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
STAT1
—
STAT2
(coimmunoprecipitation)
Tassiulas et al., Nat Immunol 2004*
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(physical association, affinity chromatography technology)
Liu et al., Proc Natl Acad Sci U S A 1998
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(physical association, affinity chromatography technology)
Gupta et al., J Immunol 1999*
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(association, biochemical)
Li et al., J Biol Chem 1996
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(direct interaction, pull down)
Fagerlund et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(physical association, affinity chromatography technology)
Dumler et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(colocalization, imaging technique)
Dumler et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
STAT1
—
STAT2
(physical association, affinity chromatography technology)
Tang et al., Cell 2007
-
MIPS CORUM Interferon-stimulated gene factor 3 transcription complex ISGF3:
Interferon-stimulated gene factor 3 transcription complex ISGF3 complex (IRF9-STAT1-STAT2)
Horvath et al., Mol Cell Biol 1996*
-
IRef Hprd Interaction:
STAT1
—
STAT2
(in vivo)
Dumler et al., J Biol Chem 1999*, Li et al., J Biol Chem 1996
-
IRef Intact Interaction:
STAT1
—
STAT2
(physical association, anti bait coimmunoprecipitation)
Tang et al., Cell 2007
-
IRef Intact Interaction:
STAT1
—
STAT2
(association, pull down)
Gupta et al., EMBO J 1996*
-
IRef Intact Interaction:
STAT1
—
STAT2
(association, competition binding)
Gupta et al., EMBO J 1996*
-
IRef Intact Interaction:
STAT1
—
STAT2
(association, coimmunoprecipitation)
Gupta et al., EMBO J 1996*
-
IRef Intact Interaction:
Complex of STAT1-STAT2-IRF9-IRF9-STAT1-STAT2
(association, anti bait coimmunoprecipitation)
Tang et al., Cell 2007
-
IRef Intact Interaction:
Complex of STAT2-STAT1
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of 14 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of STAT1-STAT2-HIST1H1A-HIST1H1T
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 244 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of 57 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 35 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 32 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of STAT1-STAT1-STAT2-STAT2
(association, anti tag coimmunoprecipitation)
Ramachandran et al., J Virol 2008*
-
IRef Ophid Interaction:
STAT1
—
STAT2
(aggregation, confirmational text mining)
Li et al., J Biol Chem 1996
-
IRef Ophid Interaction:
STAT1
—
STAT2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Usacheva et al., J Biol Chem 2001
:
Disruption of the IFNalpha receptor-RACK1 interaction abolishes not only IFNalpha induced tyrosine phosphorylation of
STAT1 but also
activation of
STAT2 , indicating that RACK1 plays a central role in early signaling through the Jak-STAT pathway
Parisien et al., J Virol 2002
:
While type II human parainfluenza virus induces
STAT2 degradation, simian virus 5
induces STAT1 degradation
Andrejeva et al., J Virol 2002
(Xeroderma Pigmentosum) :
Evidence is also presented which demonstrates that
STAT2 is
required for the degradation of
STAT1 by SV5
Gotoh et al., J Virol 2003
:
Furthermore, expression of
STAT1 enhanced the inhibitory effect of the C protein on
STAT2 activation in U3A cells
Radaeva et al., Biochem J 2004
(Carcinoma, Hepatocellular...) :
Overexpression of
STAT1 via stable transfection enhances IFN-gamma activation of STAT1, but surprisingly
attenuates IFN-alpha activation of STAT1,
STAT2 and STAT3 without affecting Janus kinase activation ... This STAT1 mediated inhibition does not require STAT1 tyrosine phosphorylation because overexpression of dominant negative
STAT1 with a mutation on tyrosine residue 701 also
blocks IFN-alpha activation of STAT1,
STAT2 and STAT3
Ramaswamy et al., Am J Respir Cell Mol Biol 2004
(Respiratory Syncytial Virus Infections) :
Furthermore, nonspecific pharmacologic inhibition of proteasome function in RSV infected cells restored
Stat2 levels and IFN dependent
activation of
Stat1
Precious et al., J Gen Virol 2005
:
As previously reported, STAT1 could not be detected in human cells that expressed SV5 V protein constitutively, whilst
STAT2 could not be
detected in human cells that expressed hPIV2 V protein, although the levels of
STAT1 may also have been reduced in some human cells infected with hPIV2 ... In contrast,
STAT1 could not be
detected , whereas
STAT2 remained present, in a variety of animal cells, including canine ( MDCK ) cells, that expressed the V protein of either SV5 or hPIV2
Dimberg et al., Scand J Immunol 2006
:
Taken together, our data suggest that ATRA induced regulation of
Stat2 , ICSBP and C/EBPepsilon is
dependent on active
Stat1 , and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation
Jia et al., PloS one 2010
:
H5N1 NS1 reduces IFN-inducible tyrosine phosphorylation of
STAT1 , STAT2 and STAT3 and
inhibits the nuclear translocation of
phospho-STAT2 and the formation of IFN-inducible STAT1 : 1-, STAT1 : 3- and STAT3 : 3- DNA complexes
Mowen et al., J Biol Chem 1998
:
Role of the STAT1-SH2 domain and
STAT2 in the activation and nuclear translocation of
STAT1