Gene interactions and pathways from curated databases and text-mining

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CD3Z — LCK

Pathways - manually collected, often from reviews:

  • BioCarta the co-stimulatory signal during t-cell activation: MHC II/TCR-CD3 complex (CD3G-HLA-DRB1-TRA@-CD3D-TRB@-HLA-DRA-CD3E-CD3Z) → LCK (T cell activation, activates)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: MHC class II complex (HLA-DRA-HLA-DRB1) → CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → CD4 (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → LCK (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D) (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: LCK → TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D) (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → ZAP70 (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: ZAP70 → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
  • BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → LCK (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  • BioCarta t cell receptor signaling pathway: LCK → TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)