UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → CBL (CBL) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → SLAP-2 (SLA2) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: SLAP-2 (SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction