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CD86 — HLA-DRA

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Raab et al., Proc Natl Acad Sci U S A 1995
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Makala et al., J Vet Med Sci 2003 : A comparison of the surface antigen expression in the progenitor DPP-Mo population and the generated DPP-DC showed a significant decrease in MHC class II levels and a marked down regulation of the co-stimulatory molecule CD86 ( B7-2 )
Makala et al., J Vet Med Sci 2003 (Toxoplasmosis) : However, a significant decrease in MHC class II antigen levels and a down regulation of the co-stimulatory molecule CD86 ( B7-2 ) were noted
Angel Rico et al., Immunol Cell Biol 2009 (Respiratory Syncytial Virus Infections) : In B lymphocytes, HRSV infection upregulated major histocompatibility complex ( MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86