Manabe et al., J Biol Chem 1999
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EDA+ FN was also more potent than EDA- FN in promoting FN-mediated tyrosine phosphorylation of p130 ( Cas ), but not focal adhesion kinase, which occurred in parallel with the activation of ERK2, suggesting that p130 ( Cas ) may be involved in activation of ERK2 Blaukat et al., J Biol Chem 1999
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Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked Pyk2 induced ERK and JNK pathways, whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2
Pujari et al., Biochim Biophys Acta 2010
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RBL induced phosphorylation of ERK1/2 and p38 MAPK was detected at 1h and 3h respectively
Dan et al., OncoTargets and therapy 2012
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EGF activated FAK ( Y397 ) and p130cas ( Y410 ) phosphorylation, while Fn activated ERK general phosphorylation