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CD40 — MMP1

Text-mined interactions from Literome

Gotoh et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : CD40-CD154 interaction augments the expression of inflammatory cytokines and MMP in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA
Oviedo-Orta et al., Immunology 2008 : Finally, we investigated whether CD40-CD40 ligand (CD40L) interactions were involved in T-cell stimulated MMP secretion from macrophages
Xia et al., Atherosclerosis 2009 (Atherosclerosis...) : Stimulation of human primary HUVECs by CD40 with its physiological ligand CD40L not only augmented MMP-1 , -9 secretion and promoted MMP-1, -9 activities, but also induced endothelial cell apoptosis and death
Wassenaar et al., Clin Exp Immunol 1999 : We show that CD40 ligation on gingival fibroblasts resulted in a decrease of their MMP-1 and MMP-3 production, while MMP-2 and TIMP-1 production were unaffected as determined by Western blot ... This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma