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CPOX — MMP1

Text-mined interactions from Literome

Pillinger et al., J Immunol 2003 : Whereas millimolar salicylates inhibited both ERK and MMP-1, nonsalicylate COX and selective COX-2 inhibitors enhanced stimulated MMP-1 release ... Our data indicate that : 1 ) ERK activation mediates MMP-1 but not MMP-13 release from FLSCs, 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK, and 3 ) COX inhibitors, by attenuating PGE inhibition of ERK, enhance the release of MMP-1 by FLSC
Spinella et al., Cancer Res 2007 (Melanoma...) : Moreover, COX-1/COX-2 inhibitors block ET-induced PGE ( 2 ) and VEGF secretion, matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties