◀ Back to CXCL12
CCL2 — CXCL12
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Damås et al., Circulation 2002
(Angina, Unstable) :
In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of
monocyte chemoattractant protein-1 , interleukin-8, matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Princen et al., J Virol 2004
:
In freshly isolated monocytes, AMD3451 inhibited the Ca ( 2+ ) flux induced by
CXCL12 and CCL4 but not that
induced by
CCL2 , CCL3, CCL5, and CCL7
Gómez et al., J Immunol 2005
(Nasal Polyps) :
Epithelial IL-6 and soluble IL-6Ralpha were shown to participate in trans signaling, interacting with membrane associated gp130 to activate
CCL-2 expression and
inhibit additional
CXCL8 production
Li et al., J Clin Endocrinol Metab 2011
(Inflammation...) :
In IL-1ß- or TNF-a stimulated first trimester decidual cells, NF?B inhibitor suppressed production of all six chemokines ; JUN NH2-terminal kinase inhibitor
inhibited secretion of
CCL2 , CCL4, and CCL5 ; and MAPK kinase and p38 inhibitor decreased production of
CXCL8
Lai et al., Int J Gynecol Cancer 2011
(Genital Neoplasms, Female...) :
Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2,
CXCL2 , IL-6, and IL-8, and in SKOV3 cells, mRNA levels of
CCL2 , CCL20, CXCL1, CXCL2, IL-6, and IL-8
increased
Zhang et al., Nat Cell Biol 2013
(Breast Neoplasms...) :
miR-126/miR-126 directly inhibit stromal cell derived factor-1 alpha ( SDF-1a ) expression, and indirectly suppress the expression of
chemokine (C-C motif) ligand 2 ( Ccl2 ) by cancer cells in an
SDF-1a dependent manner