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NOX5 — PTGS2
Text-mined interactions from Literome
Kobayashi et al., J Physiol Pharmacol 2001
(Stomach Ulcer) :
In addition the expression of
cyclooxygenase-2 and inducible nitric oxide synthase proteins increased PGE2 generation and
NOx secretion in the ulcerated stomach were
suppressed by FR167653
Barbieri et al., Cardiovasc Res 2003
(Arteriosclerosis) :
Reactive oxygen species
mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation : critical role of
NADPH oxidase
Saha et al., Cancer Res 2003
(Carcinoma, Non-Small-Cell Lung...) :
An inhibitor of
NADPH oxidase ( diphenyleneiodonium chloride )
blocked the PMA mediated induction of
COX-2 expression
Shanmugam et al., Diabetes 2004
:
In addition, an antioxidant and inhibitors of mitochondrial superoxide,
NADPH oxidase , and glucose metabolism to glucosamine also blocked high glucose
induced COX-2 expression to varying degrees
Si et al., J Biol Chem 2007
(Adenocarcinoma...) :
NADPH oxidase
NOX5-S mediates acid induced
cyclooxygenase-2 expression via activation of NF-kappaB in Barrett 's esophageal adenocarcinoma cells ... Overexpression of
NOX5-S in Barrett 's cells significantly
increased H2O2 production,
COX2 expression, PGE2 production, and thymidine incorporation
Bezdecny et al., Toxicol Appl Pharmacol 2007
:
2244-TCB mediated increases in superoxide anion were prevented by the
NADPH oxidase inhibitor apocynin or the free radical scavenger 4-hydroxy TEMPO, but neither of these inhibitors
affected the 2244-TCB induced changes in
COX-2 mRNA levels or ( 3 ) H-AA release
Zhu et al., American journal of physiology. Renal physiology 2011
:
In the presence of the COX-2 siRNA, the aldosterone induced increases in COX-2, NOX-2, and NOX-4 mRNAs and O ( 2 ) ( - ) production were completely blocked, suggesting that
COX-2 causes increased expression of
NOX-2 and NOX-4
Chen et al., Chem Res Toxicol 2012
(MAP Kinase Signaling System...) :
This 2-ABP induced
COX-2 expression was
attenuated by ROS scavenger NAC and
NADPH oxidase inhibitors apocynin and DPI
Feng et al., J Clin Invest 1995
:
In addition, NADPH stimulated
COX-2 expression, and an inhibitor of
NADPH oxidase blocked COX-2 expression induced by TNF alpha