◀ Back to IGF1
IGF1 — MMP2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MMP2
→
IGF1
(increases)
Evidence: TGF-beta 1 and IGF-I treatments significantly decreased levels of the active MMP-2
-
Reactome Reaction:
IGF1
→
MMP2
(reaction)
Mohan et al., J Endocrinol 2002, Firth et al., Endocr Rev 2002, Holly et al., Neuroendocrinology 2006, Fowlkes et al., J Biol Chem 1994, Rajah et al., Prog Growth Factor Res 1995, Rajah et al., Am J Respir Cell Mol Biol 1999
Text-mined interactions from Literome
Yoon et al., Mol Cell Biochem 2001
(Fibrosarcoma) :
Insulin like growth factor-1 selectively
regulates the expression of
matrix metalloproteinase-2 in malignant H-ras transformed cells ... Most notably,
IGF-1 can
regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization ... Most notably,
IGF-1 can
regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization ... This study demonstrates aspects of the temporal regulatory mechanisms of
MMP-2 expression in
response to
insulin-like growth factor-1 in a H-ras transformed fibrosarcoma cell line capable of metastasis formation and thereby, provides further insight into the altered growth regulatory program associated with H-ras mediated cellular transformation and malignant progression
Stearns et al., Clin Cancer Res 2003
(Prostatic Neoplasms) :
Northern blots, Western blots, and ELISAs showed that IL-10 suppressed
IGF-I induction of
MMP-2 and MT1-MMP mRNA synthesis in these cell strains ( P < 0.001 ) ... The data show that IL-10 blocks
IGF-I activation of
MMP-2 and MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
Bredin et al., Anticancer Res 2003
(Carcinoma, Non-Small-Cell Lung...) :
IGF I , IGF II, HGF and EGF
stimulated an enhanced expression and activity of the latent form of
MMP-2 and MMP-9 ... IGF I,
IGF II, HGF and EGF
stimulated an enhanced expression and activity of the latent form of
MMP-2 and MMP-9
Zhang et al., J Biol Chem 2004
(Carcinoma, Lewis Lung) :
Dual
regulation of
MMP-2 expression by the type 1
insulin-like growth factor receptor : the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals
Stawowy et al., Biochem Biophys Res Commun 2004
:
Induction of
MMP-2 by
IGF-1 was inhibited by the PI3-kinase inhibitor wortmannin, but not by the MEK-inhibitor PD98059 ... In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1 mediated signaling and cell functions, such as
IGF-1 induced
MT1-MMP/MMP-2 in VSMCs
Papatsoris et al., Trends Mol Med 2005
(Prostatic Neoplasms) :
Moreover, it has been suggested that
IGF-1 induces ligand independent activation of the androgen receptor and
enhances the expression of
matrix metalloproteinase-2 and urokinase plasminogen activator
Jenniskens et al., Osteoarthritis Cartilage 2006
:
TGFbeta2 and
IGF1 had no effect on
MMP activity
Risinger et al., J Biol Chem 2006
:
Although both PDGF-BB and
IGF-I stimulation
resulted in decreased smooth muscle alpha-actin expression and increased
matrix metalloproteinase (MMP)-2 expression, the response to IGF-I was significantly more rapid
Tang et al., Mol Nutr Food Res 2008
(Breast Neoplasms...) :
Furthermore,
IGF-1 mediated expression of
MMP-2 was significantly inhibited by resveratrol in concomitance with alteration of cell invasion
Meng et al., Cardiovasc Res 2008
:
IGF-I increased
matrix metalloproteinase (MMP)-2 and 9 activity and promoted VSMC migration, which was inhibited by knockdown of Nox4 and inactivation of Rac1
Saikali et al., Cancer cell international 2008
:
We observed that
IGF-1 increases the enzymatic activity of
MMP-2 and MMP-9 in DU145 cells
Portela et al., Genetics and molecular biology 2009
:
FSH and
IGF1 both stimulated estradiol secretion and
inhibited MMP2 and MMP9 mRNA abundance
Wirtz et al., Invest Ophthalmol Vis Sci 1998
:
IGF-I , but not IGF-II, modestly
increased trabecular stromelysin and gelatinase B but not collagenase,
gelatinase A , or tissue inhibitor of metalloproteinases 1 or 2