Gene interactions and pathways from curated databases and text-mining

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IGF1 — MMP2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Yoon et al., Mol Cell Biochem 2001 (Fibrosarcoma) : Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells ... Most notably, IGF-1 can regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization ... Most notably, IGF-1 can regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization ... This study demonstrates aspects of the temporal regulatory mechanisms of MMP-2 expression in response to insulin-like growth factor-1 in a H-ras transformed fibrosarcoma cell line capable of metastasis formation and thereby, provides further insight into the altered growth regulatory program associated with H-ras mediated cellular transformation and malignant progression
Stearns et al., Clin Cancer Res 2003 (Prostatic Neoplasms) : Northern blots, Western blots, and ELISAs showed that IL-10 suppressed IGF-I induction of MMP-2 and MT1-MMP mRNA synthesis in these cell strains ( P < 0.001 ) ... The data show that IL-10 blocks IGF-I activation of MMP-2 and MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I , IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9 ... IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Zhang et al., J Biol Chem 2004 (Carcinoma, Lewis Lung) : Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor : the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals
Stawowy et al., Biochem Biophys Res Commun 2004 : Induction of MMP-2 by IGF-1 was inhibited by the PI3-kinase inhibitor wortmannin, but not by the MEK-inhibitor PD98059 ... In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1 mediated signaling and cell functions, such as IGF-1 induced MT1-MMP/MMP-2 in VSMCs
Papatsoris et al., Trends Mol Med 2005 (Prostatic Neoplasms) : Moreover, it has been suggested that IGF-1 induces ligand independent activation of the androgen receptor and enhances the expression of matrix metalloproteinase-2 and urokinase plasminogen activator
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Risinger et al., J Biol Chem 2006 : Although both PDGF-BB and IGF-I stimulation resulted in decreased smooth muscle alpha-actin expression and increased matrix metalloproteinase (MMP)-2 expression, the response to IGF-I was significantly more rapid
Tang et al., Mol Nutr Food Res 2008 (Breast Neoplasms...) : Furthermore, IGF-1 mediated expression of MMP-2 was significantly inhibited by resveratrol in concomitance with alteration of cell invasion
Meng et al., Cardiovasc Res 2008 : IGF-I increased matrix metalloproteinase (MMP)-2 and 9 activity and promoted VSMC migration, which was inhibited by knockdown of Nox4 and inactivation of Rac1
Saikali et al., Cancer cell international 2008 : We observed that IGF-1 increases the enzymatic activity of MMP-2 and MMP-9 in DU145 cells
Portela et al., Genetics and molecular biology 2009 : FSH and IGF1 both stimulated estradiol secretion and inhibited MMP2 and MMP9 mRNA abundance
Wirtz et al., Invest Ophthalmol Vis Sci 1998 : IGF-I , but not IGF-II, modestly increased trabecular stromelysin and gelatinase B but not collagenase, gelatinase A , or tissue inhibitor of metalloproteinases 1 or 2