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GFRA1 — NCAM1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
GFRA1
→
NCAM1
(reaction)
-
Reactome Reaction:
GFRA1
→
NCAM1
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Paratcha et al., Cell 2003
:
Association of NCAM with
GFRalpha1 , a GPI anchored receptor for GDNF, downregulates NCAM mediated cell adhesion and
promotes high-affinity binding of GDNF to p140 (
NCAM ), resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET, a known GDNF signaling receptor
Sjöstrand et al., J Biol Chem 2008
:
GFRalpha1 promotes high affinity GDNF binding to
NCAM and down-regulates NCAM mediated homophilic cell adhesion, but the mechanisms underlying these effects are unknown