Ohtsuka et al., Nat Cell Biol 2004
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Blocking of endogenous ASC expression by small interfering RNA ( siRNA ) reduced the apoptotic response and inhibited translocation of Bax to mitochondria in response to p53 or genotoxic insult, suggesting that ASC is required to translocate Bax to the mitochondria
Geng et al., J Neuropathol Exp Neurol 2007
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We found that both STS- and genotoxin induced cerebellar NPC death were markedly inhibited by p53 or Bax deficiency
Hou et al., Yao Xue Xue Bao 2008
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The results showed that STS can induce Bax translocation from cytoplasm to mitochondria, Cyt-c release from mitochondria and Annexin V label
Liu et al., Cell Physiol Biochem 2008
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In addition, DIDS effectively inhibited STS induced Bax translocation to mitochondria, which was also reversed by LY294002