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PLA2G4A — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Van Putten V et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Inhibition of p38 MAP kinase or
NF-kappaB had no effect on
cPLA(2) expression
Misra et al., Arch Biochem Biophys 2001
(Calcium Signaling...) :
We conclude that alpha2M* induced
cPLA2 synthesis is
controlled by [ Ca2+ ] i levels, tyrosine kinase activity, the p21ras dependent MAPK and PI 3-kinase downstream signaling pathways, and regulation of
NFkappaB
Palomba et al., J Biol Chem 2004
:
Inhibition of
cPLA2 activity, while reducing the availability of AA, consistently
inhibited NFkappaB activation and NOS-II mRNA induction and delayed NO formation
You et al., Biochem Biophys Res Commun 2004
:
These findings indicate that PMA induces expression of
cPLA(2)alpha at the transcriptional level via an
NF-kappaB dependent mechanism
Won et al., Glia 2005
:
The inhibition of
cPLA2 by methyl arachidonyl fluorophosphates ( MAFP ) or antisense oligomer against cPLA2 and inhibition of iPLA2 by bromoenol lactone
reduced the LPS induced iNOS gene expression and
NFkappaB activation
Park et al., Biochemistry 2005
:
Inhibition of
NF-kappaB by cobrotoxin
resulted in reductions in the LPS induced expressions of COX-2, iNOS,
cPLA(2) , IL-4, and TNF-alpha in astrocytes and in COX-2 expression induced by SNP, LPS, and TNF-alpha in astrocytes
Hsieh et al., J Cell Physiol 2006
:
BK-induced
cPLA2 expression might be
due to the translocation of
NF-kappaB into nucleus which was inhibited by Hoe140, helenalin, and PD98059, implying the involvement of NF-kappaB
Luo et al., Cell Signal 2006
(MAP Kinase Signaling System) :
LPS induced
cPLA2 expression and PGE2 synthesis was
inhibited by a selective
NF-kappaB inhibitor ( helenalin ) and transfection with dominant negative mutants of NF-kappaB inducing kinase (NIK), IkappaB kinase (IKK)-alpha, and IKK-beta, consistent with that LPS stimulated both IkappaB-alpha degradation and NF-kappaB translocation into nucleus in these cells
Luo et al., Toxicol Appl Pharmacol 2008
:
Furthermore, IL-1beta induced
cPLA2 expression and PGE2 synthesis was
inhibited by a selective
NF-kappaB inhibitor ( helenalin ) or transfection with dominant negative mutants of NF-kappaB inducing kinase (NIK), IkappaB kinase (IKK)-alpha, and IKK-beta
Cheng et al., Free Radic Biol Med 2009
:
Induction of
cPLA2 by CSE was
attenuated by selective inhibitors of
NF-kappaB ( helenalin ) and AP-1 ( curcumin )
Barakat et al., Naunyn Schmiedebergs Arch Pharmacol 2009
(Brain Ischemia...) :
Expression of a constitutively active IkappaB kinase (IKK) or the
NF-kappaB subunit p65 in neurons
stimulated the transcription of
cPLA-2 , COX-2, and mPGES-1
Dimitrov et al., J Virol 1997
:
Under the same conditions, Ad infection did not inhibit TNF induced phosphorylation of
cPLA2 or TNF
activation of
NFkappaB
Thommesen et al., J Immunol 1998
:
We show that TNF induced activation of
NF-kappaB was
inhibited by the well-known selective inhibitors of
cytosolic phospholipase A2 (cPLA2) : the trifluoromethyl ketone analogue of arachidonic acid ( AACOCF3 ) and methyl arachidonyl fluorophosphate ... The trifluoromethyl ketone analogue of eicosapentaenoic acid ( EPACOCF3 ) also suppressed TNF induced
NF-kappaB activation and
inhibited in vitro
cPLA2 enzyme activity with a similar potency as AACOCF3