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AKT1 — DEPTOR
Pathways - manually collected, often from reviews:
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NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR)
→
AKT1-2-active (AKT1/AKT2)
(modification, collaborate)
Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
Evidence: mutant phenotype
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NCI Pathway Database mTOR signaling pathway:
AKT1 (AKT1)
→
mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR)
(modification, activates)
Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
AKT1 (AKT1)
→
DEPTOR (DEPTOR)
(modification, activates)
Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Peterson et al., Cell 2009
(Multiple Myeloma) :
Loss of
DEPTOR activates S6K1,
Akt , and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities ...
DEPTOR overexpression suppresses S6K1 but, by relieving feedback inhibition from mTORC1 to PI3K signaling,
activates Akt
Zhao et al., Mol Cell 2011
:
Biologically,
DEPTOR accumulation upon ßTrCP knockdown inactivates mTORC1 and
activates AKT in cancer cells to confer resistance to rapamycin and paclitaxel
Yen et al., Mol Med 2012
(Carcinoma, Hepatocellular...) :
Overexpression of
DEPDC6/DEPTOR activated
Akt and increased survival of HCC cells
Meng et al., Nat Med 2013
(Insulin Resistance) :
Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through
Deptor mediated
Akt activation