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AKT1 — GAB2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AKT1
—
GAB2
(physical association, affinity chromatography technology)
Lynch et al., EMBO J 2002*
-
IRef Biogrid Interaction:
AKT1
—
GAB2
(direct interaction, enzymatic study)
Lynch et al., EMBO J 2002*
-
IRef Hprd Interaction:
AKT1
—
GAB2
(in vitro)
Lynch et al., EMBO J 2002*
-
IRef Hprd Interaction:
AKT1
—
GAB2
(in vivo)
Lynch et al., EMBO J 2002*
-
IRef Innatedb Interaction:
AKT1
—
GAB2
(unknown, -)
Lynch et al., EMBO J 2002*
-
IRef Ophid Interaction:
AKT1
—
GAB2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lynch et al., EMBO J 2002
:
This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since
PKB constitutively associates with Gab2, phosphorylates Gab2 on a consensus phosphorylation site, Ser159, in vitro and
inhibits Gab2 tyrosine phosphorylation
Million et al., Mol Cell Biol 2004
(Cell Transformation, Neoplastic...) :
A Tel-Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae5 ) lacked Grb2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein
Gab2 and impaired
activation of phosphatidylinositol 3-kinase,
Akt , and extracellular signal regulated kinase/mitogen activated protein kinase in hematopoietic cells
Nyga et al., Biochem J 2005
:
Taken together, our results indicate that
Gab2 is
required for caSTAT5 induced cell proliferation by regulating both the
PI3K/Akt and the Ras/MAPK pathways
Mao et al., J Cell Biol 2005
:
Gab2 suppression
reduces bFGF dependent activation of
AKT but not ERK, and constitutively active AKT, but not constitutively active MEK1, reverses the hypersensitization ... Thus,
Gab2 mediated
AKT activation is required for bFGF 's protection
Abramson et al., EMBO J 2006
:
Specifically, MAFA suppresses the PLC-gamma2- [ Ca2+ ] i, Raf-1-Erk1/2, and PKC-p38 coupling pathways, while the
Fyn-Gab2 mediated activation of
PKB and Jnk is essentially unaffected
Maus et al., Cell Signal 2009
:
It has been shown in several model systems that
Gab/Dos family members may
regulate both the anti-apoptotic
PI3-K/Akt and the mitogenic Ras/MAPK pathways, still their role in B-cells have not been investigated in detail
Huang et al., Cell Mol Immunol 2008
(Calcium Signaling) :
Treatment with Gab2 siRNA significantly decreased
Gab2 expression, inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine, reduced the production of IL-4 and TNF-alpha and
inhibited the phosphorylation of
Akt , PKCdelta and p38 mitogen activated protein kinase ( MAPK )
Hunzicker-Dunn et al., Proc Natl Acad Sci U S A 2012
:
Overexpression of
GAB2 enhances FSH stimulated
AKT phosphorylation