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AKT1 — TPO
Text-mined interactions from Literome
Miyakawa et al., J Biol Chem 2001
:
TPO induced
Akt phosphorylation was significantly decreased in transfected cells suggesting an important role of SHP2 in the complex to enhance PI3K activity
Tong et al., J Exp Med 2004
:
The absence of Lnk caused enhanced and prolonged
Tpo induction of STAT3, STAT5,
Akt , and MAPK signaling pathways in CD41+ megakaryocytes
Romanelli et al., Am J Physiol Gastrointest Liver Physiol 2006
(Hepatoblastoma) :
TPO also
activated phosphatidylinositol 3-kinase (PI3K) and the downstream kinase
Akt in a time dependent manner
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007
:
Bcl-xL protein is expressed throughout megakaryopoiesis until platelets are produced, and its expression level is at least in part post-translationally regulated through
TPO mediated
Akt activation
Hitchcock et al., Blood 2008
(MAP Kinase Signaling System...) :
In contrast,
Tpo mediated
activation of positive megakaryopoiesis regulators such as ERK1/2 and
AKT is increased in FAK-null megakaryocytes, providing a plausible explanation for the observed increases in megakaryopoiesis in these mice
Hitchcock et al., Blood 2008
:
After Tpo stimulation, internalization was greatly reduced in c-Mpl Y ( 78 ) F and c-Mpl Y ( 8+78 ) F, and these cell lines also exhibited increased proliferation and increased strength and duration of Jak2, STAT5,
AKT , and ERK1/2 activation in
response to
Tpo
Soda et al., Cell Signal 2008
:
Previously we and others have shown that
TPO activates PI3K and
Akt and that this pathway is important for megakaryocyte growth ... We conclude that GSK-3beta is phosphorylated and inhibited by
TPO induced
Akt , promoting survival and proliferation in megakaryocytic cells through a pathway that does not involve beta-catenin
Erhardt et al., Exp Hematol 2009
(Thrombocytopenia) :
In signal transduction studies of washed human platelets, eltrombopag induced the phosphorylation signal transducers and activators of transcription ( STAT ) proteins with no phosphorylation of Akt, whereas recombinant human
TPO ( rhTPO )
induced the phosphorylation of
Akt as well as STAT-1, -3, and -5
Tashiro et al., Stem Cells Dev 2012
:
Furthermore, Lnk inhibition by the overexpression of the DN-Lnk gene augmented the
TPO induced phosphorylation of Erk1/2 and
Akt , indicating the enhanced sensitivity to TPO