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ITGAV — PLAUR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: LRP1 (LRP1) → uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) (translocation, activates)
  Czekay et al., J Cell Biol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta3 Integrin complex (ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) (translocation, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta3 Integrin complex (ITGAV-ITGB3) → uPAR (PLAUR) (translocation, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) → uPA/PAI-1 complex (SERPINE1-PLAU) (translocation, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) → uPAR (PLAUR) (translocation, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: LRP1 (LRP1) → uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) (translocation, activates)
  Czekay et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta5 Integrin complex (ITGAV-ITGB5) → uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) (translocation, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta5 Integrin complex (ITGAV-ITGB5) → uPAR (PLAUR) (translocation, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) → uPA/PAI-1 complex (SERPINE1-PLAU) (translocation, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) → uPAR (PLAUR) (translocation, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → PAI-1 (SERPINE1) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: PAI-1 (SERPINE1) → uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin complex (ITGAV-ITGB3) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB5) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → alphav/beta5 Integrin complex (ITGAV-ITGB5) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta5 Integrin complex (ITGAV-ITGB5) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → alphav/beta5 Integrin complex (ITGAV-ITGB5) (modification, collaborate)
  Franco et al., J Cell Sci 2006
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Franco et al., J Cell Sci 2006
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta5 Integrin complex (ITGAV-ITGB5) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Franco et al., J Cell Sci 2006
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008, Schiller et al., Mol Biol Cell 2009*
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008, Schiller et al., Mol Biol Cell 2009*
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta3 Integrin complex (ITGAV-ITGB3) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008, Schiller et al., Mol Biol Cell 2009*
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin/CK2/Nucleolin complex (PLAUR-VTN-NCL-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin/CK2/Nucleolin complex (PLAUR-VTN-NCL-PLAU-ITGAV-ITGB3) → Nucleolin (NCL) (modification, collaborate) Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Nucleolin (NCL) (modification, collaborate) Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR complex (PLAU-PLAUR) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction, other species
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR complex (PLAU-PLAUR) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction, other species
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alphav/beta3 Integrin complex (ITGAV-ITGB3) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction, other species
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: PAI-1 (SERPINE1) → uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU) → uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Src (SRC) (modification, activates) Degryse et al., Blood 1999, Kjøller et al., J Cell Biol 2001, Liu et al., Exp Cell Res 2008, Smith et al., J Cell Biol 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database Beta3 integrin cell surface interactions: pro-uPA/uPAR complex (PLAU-PLAUR) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: pro-uPA/uPAR complex (PLAU-PLAUR) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin complex (ITGAV-ITGB3) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAU-PLAUR-VTN-ITGAV-ITGB3) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAU-PLAUR-VTN-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Degryse et al., Oncogene 2001
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM ITGAV-ITGB5-PLAUR complex: ITGAV-ITGB5-PLAUR complex complex (ITGAV-ITGB5-PLAUR) Carriero et al., Cancer Res 1999
• IRef Corum Interaction: Complex of ITGB5-ITGAV-PLAUR (association, coimmunoprecipitation) Carriero et al., Cancer Res 1999
• IRef Hprd Interaction: Complex of ITGAV-ITGB5-PLAUR-ITGAV-ITGAV-PLAUR-ITGB5-ITGB5-PLAUR (in vivo) Carriero et al., Cancer Res 1999
• IRef Ophid Interaction: ITGAV — PLAUR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Gondi et al., Int J Oncol 2006 : Using FACS analysis and western blotting for the alphaVbeta3 integrin heterodimer, we determined that down regulating uPAR subsequently causes the down-regulation of the alphaVbeta3 integrin heterodimer
Wei et al., Nat Med 2008 : Mechanistically, uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1