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WNT1 — WNT3

Text-mined interactions from Literome

Cha et al., Hepatology 2004 (Carcinoma, Hepatocellular...) : We found that Wnt/beta-catenin signaling could be activated by ectopic expression of Wnt-1 in some hepatoma cells, such as Hep3B and PLC/PRF/5 cells, but not in others, such as Huh7 and Chang cells ... In conclusion, the data suggest that Wnt-1 is necessary but insufficient to activate Wnt/beta-catenin signaling in hepatoma cells and the enhanced stabilization of beta-catenin by HBx, in addition to Wnt-1, is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells
Chiba et al., Exp Hematol 2004 : In contrast, gene transfer of Wnt3 into both hTERT-stromal cells and hTERT-MSCs enhanced Wnt-betacatenin signaling, and caused remarkable morphological changes and growth retardation
Falk et al., Cell stem cell 2008 : In the midbrain, but not in the forebrain, Tgfbr2 ablation results in ectopic expression of Wnt1/beta-catenin and FGF8, activation of Wnt target genes, and increased proliferation and horizontal expansion of neuroepithelial cells due to shortened cell-cycle length and decreased cell-cycle exit
Inadera et al., Biochem Biophys Res Commun 2009 : Wnt signaling negatively regulates adipocyte differentiation, and ectopic expression of Wnt-1 in 3T3-L1 cells induces several downstream molecules of Wnt signaling, including Wnt-1 inducible signaling pathway protein ( WISP)-2
Teissedre et al., PloS one 2009 (Mammary Neoplasms, Animal) : Using axin2/conductin reporter genes we show that MMTV-Wnt1 and MMTV-DeltaN89beta-catenin activate canonical Wnt signaling within distinct cell-types
Lin et al., FEBS Lett 2011 (Prostatic Neoplasms) : We also found that Mesd suppressed Wnt/ß-catenin signaling induced by Wnt1 in prostate cancer PC-3 cells, and inhibited tumor growth in PC-3 xenograft model
Duan et al., EMBO J 2012 (Fibrosis...) : The injured regions in the heart are Wnt responsive as well and Wnt1 induces cardiac fibroblasts to proliferate and express pro-fibrotic genes
Reis et al., J Exp Med 2012 (Brain Neoplasms...) : In this study, we show that doxycycline dependent Wnt1 expression in subcutaneous and intracranial mouse glioma models induced endothelial Wnt/ß-catenin signaling and led to diminished tumor growth, reduced vascular density, and normalized vessels with increased mural cell attachment
Smolich et al., Dev Biol 1994 (Carcinoma, Embryonal) : In the presence of ectopic Wnt-1 , expression of other endogenous Wnt genes, which serve as early differentiation markers in this system, were induced without RA, which is normally required for appearance of these gene products