◀ Back to MAPK7
ARHGEF1 — MAPK7
Text-mined interactions from Literome
Garcia et al., J Biol Chem 2009
:
These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38
MAPK dependent association of HSP27 and
p115RhoGEF
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
We investigated the effects of North American ginseng ( Panax quinquefolius ), reported to reduce cardiac hypertrophy, on RhoA/ROCK and
MAPK activation in ventricular cardiomyocytes exposed to leptin ( 50 ng/ml ) and the possible role of
p115RhoGEF and p63RhoGEF in these responses ... These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of
p115RhoGEF-RhoA/ROCK dependent p38
MAPK activation