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HMGCR — IRF6

Text-mined interactions from Literome

Nishimura et al., Horm Metab Res 2006 (Bacteroidaceae Infections...) : Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression, both tumor necrosis factor-alpha and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly up-regulated HMG-CoA reductase gene expression
Feingold et al., J Lipid Res 1993 : Moreover, LPS increases hepatic HMG-CoA reductase mRNA levels ( low dose 3.1-fold, high dose 14.2-fold )
Memon et al., Endocrinology 1993 : Finally, pretreatment of mice with anti-TNF antibodies, but not with an IL-1 receptor antagonist, blocked the effect of LPS on serum cholesterol and TG levels, hepatic cholesterol and fatty acid synthesis, and hepatic HMG-CoA reductase activity