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IQGAP1 — RHO

Text-mined interactions from Literome

Casteel et al., J Biol Chem 2012 (Breast Neoplasms) : IQGAP1 knockdown also reduced the amount of GTP bound to GTPase-deficient RhoA/C mutants, suggesting that IQGAP enhances Rho activation by GEF ( s ) or stabilizes Rho-GTP
Osman et al., Biochim Biophys Acta 2013 (Diabetes Complications...) : Here we discuss how IQGAP1-Exocyst , through differential interactions with Rho-type of small guanosine triphosphatases ( GTPases ), acts as a rheostat that modulates the mTORC1-Akt and MAPK signals, and integrates ß-cell function and mass with insulin signaling, thus providing a molecular mechanism for cancer initiation in diabetes