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RAC3 — RASGRF1

Text-mined interactions from Literome

Kiyono et al., J Biol Chem 2000 : Tyrosine phosphorylation of Ras-GRF1 is critical for the induction of Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates Ras-GRF1 , thereby inducing Rac-GEF activity ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates Ras-GRF1 , thereby inducing Rac-GEF activity
Drake et al., Genes, brain, and behavior 2011 : Additional analyses of neonates showed imprinted Rasgrf1 transcript selective to olfactory bulb even in mice that were null for Rasgrf1 in the rest of the brain and showed that Rasgrf1 affects Ras and Rac activation in the brain
Talebian et al., J Mol Neurosci 2013 : RasGrf1 can activate both Ras and Rac , via intrinsic Cdc25 and DH domains, respectively, suggesting that the activation of both could contribute to this process ... Moreover, we find that H-Ras over-expression rescues the loss of neurite outgrowth observed with a Rac minus mutant and that RasGrf1 differentially stimulates NGF dependent activation of Rac or Ras, depending on cell type