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CASP6 — CREB5
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Rabelo et al., Biochem Biophys Res Commun 2003
(Fibrosarcoma) :
The butyrate effect was shown to be dependent on caspase activation, once
caspase inhibitors
restored phosphorylation of ERK1/2 and
CREB in 2C4 cells
Lee et al., Toxicol Appl Pharmacol 2003
:
2,2',4,6,6'-pentachlorobiphenyl ( PCB 104 ) induces apoptosis of human microvascular endothelial cells through the
caspase dependent activation of
CREB
Jover-Mengual et al., Endocrinology 2007
(Ischemia...) :
We demonstrate that global ischemia promotes early dephosphorylation and inactivation of ERK1 and the transcription factor cAMP-response element binding protein ( CREB ), subsequent down-regulation of the antiapoptotic protein Bcl-2, a known gene target of estradiol and
CREB , and
activation of
caspase-3
Sarkar et al., Diabetologia 2007
(Cadaver) :
Expression of
CREB mutants in human islets
resulted in significant ( p < 0.001 ) activation of
caspase-9 , a key regulatory enzyme in the mitochondrial pathway of apoptosis, when compared with islets transduced with adenoviral beta galactosidase
Ghorpade et al., Mol Cell Biol 2012
:
The miR-155 triggered activation of
caspase-3 , BAK1, and cytochrome c translocation
involved signaling integration of MAPKs and epigenetic or posttranslational modification of histones or
CREB