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ARG2 — SMO

Text-mined interactions from Literome

Tummala et al., Oncol Rep 2010 (Carcinoma...) : Pt-, Pd-spermine complexes induced significant down-regulation of SMO, arginase 2 and NRF-2, with no change in SSAT, while cisplatin as a single agent or in combination with DENSPM induced significant up-regulation of SSAT and SMO ... Pt-, Pd-spermine complexes induced significant down-regulation of SMO, arginase 2 and NRF-2, with no change in SSAT, while cisplatin as a single agent or in combination with DENSPM induced significant up-regulation of SSAT and SMO
Chaturvedi et al., Amino Acids 2012 (Cell Transformation, Neoplastic...) : In summary, L-Arg metabolism by the arginase-ODC pathway and the activation of SMO leads to H. pylori induced DNA damage and immune dysregulation through polyamine mediated oxidative stress and impairment of antimicrobial NO synthesis